Relevant Publications

Surrogate-based optimization of expensive flowsheet models for continuous pharmaceutical manufacturing

Journal of Pharmaceutical Information 2013

F. Boukouvala F.J. Muzzio M.G. Ierapetritou

Simulation-based optimization is a research area that is currently attracting a lot of attention in many industrial applications, where expensive simulators are used to approximate, design, and optimize real systems. Pharmaceuticals are typical examples of high-cost products which involve expensive…

Computer-Aided Flowsheet Simulation of a Pharmaceutical Tablet Manufacturing Process Incorporating Wet Granulation

Journal of Pharmaceutical Innovation 2013

A. Chaudhuri F. Boukouvala L. Mioduszewski M. Sen M.G. Ierapetritou R. Ramachandran R. Zhou

In this work, a dynamic flowsheet model for the production of pharmaceutical tablets through a continuous wet granulation process is developed. The unit operation models which are integrated to compose the process line form a hybrid configuration which is comprised…

An integrated approach for dynamic flowsheet modeling and sensitivity analysis of a continuous tablet manufacturing process

Computers & Chemical Engineering 2012

F. Boukouvala F.J. Muzzio M.G. Ierapetritou R. Ramachandran V. Niotis

Manufacturing of powder-based products is a focus of increasing research in the recent years. The main reason is the lack of predictive process models connecting process parameters and material properties to product quality attributes. Moreover, the trend towards continuous manufacturing…

Computer aided design and analysis of continuous pharmaceutical manufacturing processes

Computer-Aided Process Engineering (Proceedings of European Symposium of Computer-Aided Process Engineering 21) 2011

A. Vanarase F. Boukouvala FJ Muzzio MG Ierapetritou R. Ramachandran

Dynamic flowsheet modeling and simulation is a pre-requisite for the design, analysis, control and optimization of an integrated process. Whilst several integrated modeling and simulation tools (commercial and non-commercial) have proven to be effective for fluids processes, their use has…

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