Relevant Publications

Derivative-free optimization for expensive constrained problems using a novel expected improvement objective function

AIChE Journal 2014

Fani Boukouvala M.G. Ierapetritou

In this work, an algorithm for the optimization of costly constrained systems is introduced. The proposed method combines advantages of global- and local-search algorithms with new concepts of feasibility space mapping, within a framework that aims to find global solutions…

Surrogate-based optimization of expensive flowsheet models for continuous pharmaceutical manufacturing

Journal of Pharmaceutical Information 2013

F. Boukouvala F.J. Muzzio M.G. Ierapetritou

Simulation-based optimization is a research area that is currently attracting a lot of attention in many industrial applications, where expensive simulators are used to approximate, design, and optimize real systems. Pharmaceuticals are typical examples of high-cost products which involve expensive…

Feasibility analysis of black-box processes using an adaptive sampling kriging-based method

Computers & Chemical Engineering 2012

F. Boukouvala F.J. Muzzio M.G. Ierapetritou

This paper presents a new approach for performing feasibility analysis over a multivariate factor space when the explicit form of a process model is lacking or when its evaluation is expensive. Specifically, two issues are addressed: feasibility evaluation of black-box…

Design Space of pharmaceutical processes using data-driven based methods

Journal of Pharmaceutical Innovation 2010

F. Boukouvala F.J. Muzzio M.G. Ierapetritou

Introduction The identification and graphical representation of process design space are critical in locating not only feasible but also optimum operating variable ranges and design configurations. In this work, the mapping of the design space of pharmaceutical processes is achieved…

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