Highlights

Dimensionality reduction for production optimization using polynomial approximations

Computational Geosciences 2017

B. Beykal Christodoulos A Floudas E. Gildin Fani Boukouvala N. Sorek

The objective of this paper is to introduce a novel paradigm to reduce the computational effort in waterflooding global optimization problems while realizing smooth well control trajectories amenable for practical deployments in the field. In order to overcome the problems…

ARGONAUT: AlgoRithms for Global Optimization of coNstrAined grey-box compUTational problems

Optimization Letters 2016

Christodoulos A Floudas Fani Boukouvala

The algorithmic framework ARGONAUT is presented for the global optimization of general constrained grey-box problems. ARGONAUT incorporates variable selection, bounds tightening and constrained sampling techniques, in order to develop accurate surrogate representations of unknown equations, which are globally optimized. ARGONAUT…

Global Optimization Advances in Mixed-Integer Nonlinear Programming, MINLP, and Constrained Derivative-Free Optimization, CDFO

European Journal of Operational Research 2015

Christodoulos A Floudas Fani Boukouvala Ruth Misener

This manuscript reviews recent advances in deterministic global optimization for Mixed-Integer Nonlinear Programming (MINLP), as well as Constrained Derivative-Free Optimization (CDFO). This work provides a comprehensive and detailed literature review in terms of significant theoretical contributions, algorithmic developments, software implementations…

An integrated approach for dynamic flowsheet modeling and sensitivity analysis of a continuous tablet manufacturing process

Computers & Chemical Engineering 2012

F. Boukouvala F.J. Muzzio M.G. Ierapetritou R. Ramachandran V. Niotis

Manufacturing of powder-based products is a focus of increasing research in the recent years. The main reason is the lack of predictive process models connecting process parameters and material properties to product quality attributes. Moreover, the trend towards continuous manufacturing…

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